In 2010, The Michael J. Fox Foundation (MJFF) invested heavily in a new initiative to identify biomarkers of Parkinson’s disease and launched the Parkinson’s Progression Markers Initiative (PPMI), a large-scale clinical study conducted at a network of clinical sites around the world focused on identifying and validating Parkinson’s disease biomarkers. PPMI has emerged as a cornerstone in the field’s growing understanding of Parkinson’s pathology and as a model for following multiple cohorts of significant interest.

The study has enrolled more than 1,400 participants across the globe – from the U.S. to Greece to Australia – with some traveling across states and regions to participate at a clinical study site. Participants are asked to visit sites for at least five years, more frequently in the first years and then subsequent visits are made annually. To aid recruitment and retention, PPMI needs participants to be able to get to and from study sites easily and be reimbursed in a timely manner. Greenphire’s ClinCard payment and reimbursement solution was implemented to overcome these hurdles.

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